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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-359 |
| Subject |
A fluorescent probe for detecting mitochondrial nitroreductase in cancer cells |
| Authors |
Jung Won Yoon, Min Hee Lee*
Department of Chemistry, Sookmyung Women's University, Korea
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| Abstract |
Activity of nitroreductase (NTR) is concerned to be a representative feature of tumor cells. NTR is overexpressed in biological hypoxia status in organisms, so selective and sensitive detection of NTR is focused on hypoxia diseases including cancer. In particular, we are interested in the NTR activity associated with the mitochondria in hypoxic conditions. Therefore, we showed a NTR probe that can target the mitochondria in live cells and give a fluorescence change in response to the NTR activity. In this study, fluorescent probes (1a-c) were designed as a mitochondrial NTR imaging probe. Upon reacting with NTR, the 1a-c showed a strong fluorescence increase and visual color change from yellow to red. We are studding the detailed sensing mechanism of the probes and the bioimaging experiments are ongoing. |
| E-mail |
iyjw1118@sookmyung.ac.kr |
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121st General Meeting of the KCS