121st General Meeting of the KCS

Type Poster Presentation
Area Material Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code MAT.P-360
Subject Hematocompatibility of layered double hydroxides depending on size
Authors Hyoung-Mi Kim, Soojung Ko, Jae-Min OH*
Chemistry and Department of Medical Chemistry, Yonsei University, Korea
Abstract Layered double hydroxide (LDH), which consists of mixed metal hydroxide nanolayers and interlayer anions, is one of the most attractive nanomaterials in drug delivery system for intravenous injection. In this study, we have evaluated the biological behaviors of LDH nanomaterials in human blood environment depending on their particle size and morphology. LDH nanomaterials with controlled size and morphology were prepared by regulating crystal growth mechanism through hydrothermal treatment or urea hydrolysis. Powder X-ray diffraction patterns and scanning electron microscopic analyses indicated that all the three LDH samples prepared in different condition possess well-crystallized hydrotalcite-like structure with average diameter ~ 150, ~ 350 and 2,000 nm size. The former two had aspect ratio ~ 3 and the last one ~ 25 exhibiting short hexagonal column-like and plate-like morphology, respectively. In order to evaluate the possible interaction of LDH nanomaterials with human blood components, we investigated the effect of LDHs on hemolysis and viability of red blood cells (RBCs). The RBCs were visualized with both optical and electron microscopies to examine the morphological change and cell-LDH interaction at the interface, showing a possible attack by large plate like LDHs in high administration concentration. The human blood plasma mixed with different sized LDHs did not show significant aggregation or absorption of proteins on LDHs. It was concluded that the LDH nanomaterials are fairly compatible to blood components although the morphology can affect their interaction with cells.
E-mail annabb@hanmail.net