121st General Meeting of the KCS

Type Poster Presentation
Area Material Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code MAT.P-363
Subject Chelator-Free Incorporation of Zr-89 in Hematite Nanoclusters using Glutamic acid through One-pot Hydrothermal Synthesis
Authors Pyeong Seok Choi, JEONG HOON PARK*
Korea Atomic Energy Research Institute, Korea
Abstract Zr-89 utilized in Positron Emission Tomography (PET) has been the spotlight in nanomedicine due to relatively long half-life required for the measurement of long-term in vivo behavior of the nanoparticles. The metallic radioisotope usually needs the chelator for conjugation with bioactive nanomaterials as a radiopharmaceutical. However, the chelator attached on surface of nanoparticle could induce unprecedented alteration of its properties due to the variation in the surface charge of the nanoparticles and may reduce innate targeting system. We successfully tried to introduce Zr-89 on the hematite nanocrystals by glutamic acid. Chelator free rice-shaped Zr-89 incorporated hematite nanoclusters were formed by using simply one-pot hydrothermal synthesis for 24 h. The hematite nanoclusters were characterized and their average length and width were found to be 180 and 82 nm respectively. Controlling of the nanometer size was achieved by using formic acid as a capping agent. The respective chemical composition of Fe, Zr, glutamic acid and formic acid was confirmed by IR, ICP, XPS and EDX. As a result, Zr-89 incorporated nanoclusters with 98%, of synthesis efficiency were obtained and its stability was significantly high in biological mediums which was further confirmed by radio-TLC and DLS for the span of a week. To conclude, Zr-89 incorporated hematite nanoclusters were synthesized through fairly simple self-assembly mode in aqueous solution and radio-tagging of hematite nanoclusters using Zr-89 for PET diagnostic nanomedicine without chelator was achieved for the very first time.
E-mail cps@kaeri.re.kr