121st General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code MEDI.P-585
Subject Fast Degradable Polycaprolactone Microspheres for Drug Delivery
Authors Hyun Jung Lee, MINJIN LEE, Yuna Moon, MinHee Park, Byeongmoon Jeong*
Department of Chemistry and Nano Science, Ewha Womans University, Korea
Abstract Polycarprolactone (PCL) was reported a long time ago; however, its use in biomedical applications has not been extensively investigated in comparison with poly(lactide-co-glycolide) (PLGA) due to its too slow degradation profile, even though the production process of PCL is much less expensive than that of PLGA. The returning of PCL as a popular biomaterial these days is mainly due to the tissue engineering applications of the PCL. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer as a fast degradable PCL (PCL-OX). PCL-OX with a molecular weight of 100,000 Daltons exhibited a melting point of 44.7 oC and a crystallinity of 40%. PCL-OX microspheres containing paclitaxel, a model drug, were prepared by the oil-in-water emulsion method and were compared with PLGA microspheres containing the same drug. In-vitro release of paclitaxel from the PCL-OX microspheres was slower than that from the PLGA microspheres. However, the in-vivo application of the PCL-OX microspheres by the subcutaneous injection into rats provided a steady plasma drug concentration of 6-9 μg/ml over 28 days, similar to that of the PLGA microspheres. The degradation of PCL-OX was significantly accelerated by hydrogen peroxide more than PLGA, which induced degradation of PCL-OX faster in in-vivo than in-vitro conditions. The PCL-OX microspheres showed a similar tissue compatibility to that of PLGA microspheres in the subcutaneous layer of rats, with a marginal tissue irritation over 28 days. These findings suggest that PCL-OX is a useful biomaterial that solves the slow degradation problems of PCL, and thus may find use in other biomedical applications as an alternative to PLGA.
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