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| Type |
Poster Presentation |
| Area |
Material Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
MAT.P-368 |
| Subject |
Gold nanorods conjugated defective TiO2 nanoparticles for enhanced photodynamic cancer therapy and photothermal therapy in biomedical application |
| Authors |
Jooran Lee
Medical Device Development Center, OSONG Medical Innovation Foundation, Korea |
| Abstract |
Defective TiO2 nanoparticles (d-TiO2 NPs) easily infiltrate the membrane and cytoplasm of cancer cells via endocytosis. And then d-TiO2 NPs generate reactive oxygen species (ROS) leading to the destruction of cancer cells upon irradiation with visible light. However, the maximal absorption wavelength of d-TiO2 NPs are located in the visible region, which is not suitable for subcutaneous treatment. In contrast, gold nanorods (Au NRs) convert light energy into heat energy to kill cancer cells with NIR range (650 nm - 900 nm) light, which can penetrate deeply into biological tissue. Also, increased ambient temperature with Au NRs make an increase in ROS generation for photodynamic therapy (PDT). Therefore, a combination of PDT with photothermal therapy (PTT) attracts interest because PDT and PTT give absolutely different effects on the cancer cells, the combination of these two treatments possibly give synergistic effects.
Hereby, we fabricated Au NRs conjugated d-TiO2 NPs (Au-TiO2 NPs) which exhibit the generation of ROS as well as photothermal effect for the simultaneous application of PDT and PTT. The combination of PDT and PTT treatment caused a significant increase in cell death compared to the each treatment. As a result, Au-TiO2 NPs are promising nanomaterials for future in vivo phototherapy of cancer.
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| E-mail |
jrlee@kbiohealth.kr |
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121st General Meeting of the KCS