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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-589 |
| Subject |
Parallel Synthesis of 2-Amino-4-Alkoxy-5-Phenylmethanone Thiazole Derivatives |
| Authors |
Ye Ji Kim, Young Dae Gong*
Department of Chemistry, Dongguk University, Korea
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| Abstract |
Heterocyclic core skeletons serve as ideal scaffolds on which pharmacophores are arrange to provide potent and selective drugs. This is especially true for five-member ring heterocyclic compounds, which serve as the core components of a large number of substances that possess a broad range of interesting biological activities. Among these heterocycles, many natural and synthetic medicinally important compounds contain thiazole as essential moieties with numerous therapeutic activities, such as antibacterial, antioxidant, diuretic, antifungal, antitubercular, anti-inflammatory, anticonvulsant, anti-HIV, antidiabetic, antihypertensive, anti-Alzheimer and anticancer activities. In this reason, we have decided to synthesize diverse 2-amino-4-alkoxy-5-phenylmethanone thiazole derivatives in solution-phase. The synthesis of library starts form the alkylation of the benzylamine following attachment of ethoxycarbonyl isothiocyanate. Further cyclization Ethyl (N-alkyl-benzylcarbamothioyl)carbamate with bromoacetophenone in the presence of the dimethylformamide, which is key step of the synthetic approach, we could obtain desired library of 2-amino-4-alkoxy-5-phenylmethanone thiazole derivatives. |
| E-mail |
kyj4660@hanmail.net |
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121st General Meeting of the KCS