121st General Meeting of the KCS

Type Poster Presentation
Area Material Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code MAT.P-380
Subject Synthesis of porous gold nanoplates by using reducing agent-assisted excessive galvanic replacement method and good efficient for gene-thermo cancer therapy
Authors Kyunglee Kang, Hongje Jang1,*
Chemistry, Kwangwoon University, Korea
1Department of Chemistry, Kwangwoon University, Korea
Abstract Gold (Au) nanoparticles have been studied and applied in various nano-bio fields including sensors, imaging, and therapy due to their advantages which represented as good biocompatibility, unique physicochemical and optical properties. The development of synthetic methods for Au nanoparticles with different size, morphology, and surface properties has been a long-standing concern for the control of these properties. Galvanic replacement reaction, one of the most novel synthetic methods used to form sophisticated structures such as hollow nanoshells or nanoframes, has been widely used since its first report in 2003. Here, we report new synthetic strategy to prepare porous Au nanoplates (pAuNPs) through reducing agent-assisted excessive galvanic replacement which accomplished by competitive reaction between replacement and regrowth by excessive addition of replacing ions and existence of reducing additives. Under the control of reaction kinetics by replacing ion and additives, various morphologies as holey-nanoplates, nanoframes, porous nanoplates, bumpy nanoplates were successfully manufactured. Prepared pAuNPs exhibited excellent biocompatibility, loading capacity against thiolated gene, and highly efficient photothermal conversion. The combination of these characteristics could finally show the possibility of gene-thermo combinational therapy for hepatocarcinoma Huh7 cells.
E-mail kklee9404@gmail.com