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| Type |
Poster Presentation |
| Area |
Material Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
MAT.P-384 |
| Subject |
Preparation of porous Au, Pt, and Pd nanoplates and gene-photo cancer therapeutic efficiency comparison |
| Authors |
Hongje Jang*, Woojun Shin1
Department of Chemistry, Kwangwoon University, Korea
1Chemistry, Kwangwoon University, Korea
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| Abstract |
Since the development of noble metal nanochemistry, many biomedical researches against numerous incurable diseases have been accomplished in decades. Among them, cancer has been regarded as a subject of great interest and urgent topicdue to its fatality and widespread. Various treatment strategies including chemo-, gene-, photodynamic-, and photothermo-therapy were developed to overcome this notorious disease.
Up to now, gold (Au) nanoparticles have been considered as the best candidate for this purpose because of their excellent biocompatibility, inertness, robustness, plasmonic properties, and surface conjugation feasibility. We were wondering whether Au is the best efficiency of all the noble metal elements present in cancer therapeutic application. Based on our reducing agent-assisted excessive galvanic replacement method, we successfully prepared porous Au, Pt, and Pd nanoplates to resolve our questions through comparative experiments. As a result, we figured out that palladium (Pd) exhibited in the best efficiency in biocompatibility, cargo payload capacity, and photothermal therapy with advantage in price. We believe that present report will endow the opportunities and possibilities to further cancer therapy application from the viewpoint of elements that have been underestimated.
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| E-mail |
swjshin@gmail.com |
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121st General Meeting of the KCS