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|
| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Material Chemists |
| Room No. |
Samda Hall A |
| Time |
THU 10:06-: |
| Code |
MAT.O-7 |
| Subject |
Enhanced Delivery of Topoisomerase I Inhibitors Encapsulated in Carbon Nanotubes |
| Authors |
BYUMSEOK KOH
Bio and Drug Discovery Division, Korea Research Institute of Chemical Technology, Korea |
| Abstract |
Topoisomerase I inhibitors have shown potent anticancer activity, but poor water solubility limits their clinical application. Utilizing carbon nanotubes as a protective shell for water insoluble SN-38 and CPT, while maintaining compatibility with aqueous media via functionalized surface can thus be a strategy to overcome this limitation. With hydrophobic-hydrophobic interaction, SN-38 and CPT were successfully encapsulated in functionalized single-walled carbon nanotubes (fCNTs). Cell proliferation inhibition effect and drug distribution profile inside cells suggest that these drug encapsulated carbon nanotubes can serve as promising delivery strategy for water insoluble drugs. |
| E-mail |
BKOH@KRICT.RE.KR |
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121st General Meeting of the KCS