|
Type |
Poster Presentation |
Area |
Physical Chemistry |
Room No. |
Event Hall |
Time |
4월 20일 (금요일) 11:00~12:30 |
Code |
PHYS.P-110 |
Subject |
Synthesis, characterization, and enhanced cancer-imaging application of trans-activator of transcription (TAT) peptide-conjugated ultrasmall gadolinium oxide nanoparticles |
Authors |
Mohammad Yaseen Ahmad, Gang Ho Lee1,* Kyungpook National University, India 1Department of Chemistry, Kyungpook National University, Korea |
Abstract |
We prepared gadolinium oxide (Gd2O23) nanoparticles (GNPs) coated with a trans-activator of transcription (TAT) peptide with cell-penetrating ability (i.e., TAT-GNPs) through one-pot process. We characterized the particle diameter, surface-coating structure, water proton relaxivities, and in vitro cellular toxicities of the TAT-GNPs. We measured in vivo T1 magnetic resonance (MR) images in a model nude mouse with liver cancer prior and posterior to intravenous administration. The average particle diameter of the GNPs was 1.5 nm. The sample solution exhibited a longitudinal water proton relaxivity (r1) of 18.2 s-1mM-1 (r2/r1 = 1.6, r2= transverse water proton relaxivity), which is 4 - 5 times higher than those of commercial Gd-chelates. The in vivo T1 MR images exhibited positively (or T1) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT-GNPs acted as an enhanced cancer-imaging agent similar to the cancer-targeting agent in T1 MR imaging (T1 MRI). |
E-mail |
yaseen.knu@gmail.com |
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