121st General Meeting of the KCS

Type Poster Presentation
Area Physical Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code PHYS.P-110
Subject Synthesis, characterization, and enhanced cancer-imaging application of trans-activator of transcription (TAT) peptide-conjugated ultrasmall gadolinium oxide nanoparticles
Authors Mohammad Yaseen Ahmad, Gang Ho Lee1,*
Kyungpook National University, India
1Department of Chemistry, Kyungpook National University, Korea
Abstract We prepared gadolinium oxide (Gd2O23) nanoparticles (GNPs) coated with a trans-activator of transcription (TAT) peptide with cell-penetrating ability (i.e., TAT-GNPs) through one-pot process. We characterized the particle diameter, surface-coating structure, water proton relaxivities, and in vitro cellular toxicities of the TAT-GNPs. We measured in vivo T1 magnetic resonance (MR) images in a model nude mouse with liver cancer prior and posterior to intravenous administration. The average particle diameter of the GNPs was 1.5 nm. The sample solution exhibited a longitudinal water proton relaxivity (r1) of 18.2 s-1mM-1 (r2/r1 = 1.6, r2= transverse water proton relaxivity), which is 4 - 5 times higher than those of commercial Gd-chelates. The in vivo T1 MR images exhibited positively (or T1) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT-GNPs acted as an enhanced cancer-imaging agent similar to the cancer-targeting agent in T1 MR imaging (T1 MRI).
E-mail yaseen.knu@gmail.com