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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-378 |
| Subject |
New NIR emitting dyes for bioimaging application |
| Authors |
Changwook Song, Kyo Han Ahn*
Department of Chemistry, Pohang University of Science and Technology, Korea
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| Abstract |
Fluorescence imaging with fluorescent dyes has been widely used in tissue and cellular imaging because of its advantages such as non-invasive detection, high selectivity and sensitivity for analytes, and simple operation with low cost. However, most of known fluorescent dyes suffer from autofluorescence interference from biomolecules and shallow penetration depth, which limit their use on clinical site. A two-photon absorbing dye that emits in the far-red or NIR region can be a solution to those issues. Such dyes allow us to image of tissue at deeper penetration depth with reduced autofluorescence interference.1
We report naphthalene–based hemicyanine dyes, which have significant two-photon absorbing property and also emit in the NIR region. The new dyes have high quantum yields, good photostability, and are expected to have minimal autofluorescence interference in two-photon imaging of tissue. Synthesis, characterization of photophysical properties, stability toward reactive oxygen species and biothiols, and an application of the dyes will be presented.
1. Zipfel, W. R.; Williams, R. M.; Webb, W. W. Nat. Biotechnol. 2003, 21, 1369.
2. Song and co-workers, manuscript under preparation.
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| E-mail |
alchemy@postech.ac.kr |
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121st General Meeting of the KCS