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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-596 |
| Subject |
Room-temperature radiolabeling can be achieved by Al-18F chelation |
| Authors |
Phoung Tu Huynh, Rammyani Pal, Jeongsoo Yoo*
Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Korea
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| Abstract |
18F, with a half-life of 110 min, is the most widely used radionuclide for PET imaging. A significant impediment to this traditional application of 18F, however, is the requirement for tedious coupling of the radionuclide to a carbon atom on the targeting agent. Al-18F radiofluorination has recently been developed as an alternative method for facile radiolabeling; however, the harsh conditions required for Al-18F complexation have restricted the widespread application of this technique to heat-sensitive biomolecules. In this work, we examine the efficiency of Al-18F chelation by a variety of available macrocyclic chelators. Additionally, we optimized the radiolabeling conditions to achieve radiolabeling at ambient temperatures and reduce the reaction time to 2 min. |
| E-mail |
huynhtuphuong2110@yahoo.com |
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121st General Meeting of the KCS