Self-assembled monolayers (SAMs) on mineral has been attracted in the area of electronic device, molecular recognition, control of physicochemical properties, and application of nanocrystals for design of advanced materials. While there are lots of application of SAMs, the development of conformal and stable monolayers on mineral has received little attention. Here, we derived inspiration from mussel foot protein-3,5,6 and developed separated catechol & amine coating system to maximize adhesive properties by suppressing cohesive. Uniform and stable monolayer coating to nanoparticles as well as bulk materials have been fabricated successfully and the nano-coating layer have been analyzed extensively and simulated by DFT to elucidate mechanism of formation of nano-coating. As a result, we discovered that in-situ generated newly designed catechol-amine adduct play a key role in the outstanding nano-coating performance. Additionally, excellent performance of in-vivo angiographic achieved by nanocoating applied-magnetic nanoparticles shows general applicant prospects for the nano-coating.