| Abstract |
Ir(III) complexes have attracted much attentions in bio-imaging and targeted therapies due to their outstanding advantages such as large Stokes shift, short incubation time, long luminescence lifetime, enhanced photo-stability and simple color tuning method. Furthermore, Ir(III) complexes showed remarkable efficiency of reactive oxygen species (ROS) generation as photosensitizers via electron (type I) and energy transfer (type II). Despite these great characteristics, the use of Ir(III) complexes as therapeutic agents has been limited because of their poor biocompatibility and water solubility.
Herein, we provide reduction-triggered self-cross-linked polymer based Ir(III) complexes for enhancing the cell viability, TIr3PSSG. We synthesized iridium complexes(TIr3) encapsulated in self-cross-linked hyperbranched polyglycerol nanogels(PSSG nanogels) by using the thiol-disulfide intermolecular exchanges. This Ir(III) complex involved nanogel was much soluble in physiological environments compared to the Ir(III) complex. With these formed nanoparticles, we expect enhancement of cell viability and photo-toxicity index for cancer cells due to better biocompatibility and enhanced permeability and retention (EPR) effect of nanoparticles.
References
1. Nam, J. S.; Kang, M. G.; Kang, J.; Park, S. Y.; Lee, S. J.; Kim, H. T.; Seo, J. K.; Kwon, O. H.; Lim, M. H.; Rhee, H. W.; Kwon, T. H., Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications. J. Am. Chem. Soc. 2016, 138 (34), 10968-77.
2. Son, S.; Shin, E.; Kim, B.-S., Redox-Degradable Biocompatible Hyperbranched Polyglycerols: Synthesis, Copolymerization Kinetics, Degradation, and Biocompatibility. Macromolecules 2015, 48 (3), 600-609.
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121st General Meeting of the KCS
