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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
BIO.P-271 |
| Subject |
Reduced inflammation and bacterial adhesion on Gore-Tex implants via covalent phospholipid-mimic polymer grafting |
| Authors |
Sunah Kang, Yan Lee*
Division of Chemistry, Seoul National University, Korea
|
| Abstract |
Gore-Tex is widely used as an implantable biomaterial because of its favorable mechanical properties and biochemical inertness derived from its chemical structure, polytetrafluoroethylene (PTFE). However, some pathogenic bacteria can proliferate in the porous network without clearance by host immune cells and cause serious complications around the implants. In addition, Gore-Tex surfaces sometimes provoke foreign body reactions due to the limited biocompatibility. To alleviate these complications, we covalently grafted poly(2-methacryloyloxylethyl phosphorylcholine) (PMPC), a representative biomembrane-mimic polymer, on the ePTFE surface by partial reduction followed by UV-induced polymerization with cross-linkers. PMPC grafting effectively decreased serum protein adsorption and fibroblast adhesion on the ePTFE surface. Also, the PMPC-grafted ePTFE surface showed a dramatic inhibition of the adhesion and growth of S. aureus, a typical pathogenic bacterium in implants. When PMPC-grafted ePTFE plates were implanted in the backs of rats, inflammation-related factors in the tissues around the plates were reduced obviously. Grafting PMPC on the surface of ePTFE implants may be an effective strategy for the introduction of anti-inflammatory and anti-bacterial properties in biomedical applications. |
| E-mail |
lechat@snu.ac.kr |
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121st General Meeting of the KCS