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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-602 |
| Subject |
Two-Photon Dual Color Imaging of Sodium and Magnesium Ion Activities |
| Authors |
seok eun yoo, Eun-young Yoon1,*, BONG RAE CHO2,*, Jung-Nyoung Heo1,*
Chungnam National University, Korea
1Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Korea
2Department of Chemistry, Daejin University, Korea
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| Abstract |
Metal ions in our body play an important role in many physiological and pathological processes.
For proper cell function, metal ion homeostasis must be maintained.
To detect the homeostasis of sodium and magnesium ions, we have developed dual-color two-photon probes with different fluorophores. Each probe selectively monitored magnesium and sodium ions.
We have designed two-photon probes for Mg2+ derived from benzoxazol naphthalene as a fluorophore and 2,5-Diaminophenol as a receptor for Mg2+ respectively.
In addition, we have utilized fluorene derivatives for Na+ as a fluorophore and 1,7-diaza-15-crown-5 ether as a receptor for Na+.
In this way, here we will describe dual color images of sodium and magnesium in living cell, and the relationship between sodium and magnesium through dual color images will be helpful in physiological and pathological studies.
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| E-mail |
yse610@krict.re.kr |
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121st General Meeting of the KCS