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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-415 |
| Subject |
Development of new steroid-based amphiphiles for membrane protein study |
| Authors |
EHSAN MUHAMMAD, Pil Seok Chae1,*
Department of Bio-Nano Engineering, Hanyang University, Korea
1Department of Bionano Engineering, Hanyang University, Korea
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| Abstract |
Membrane proteins are key components in cell membranes and play key roles in fundamental cellular processes such as metabolism, signalling, and ion transport. Structural information on membrane proteins is essential for designing new drugs, but is limited mainly due to their incompatibility with an aqueous environment. Detergents, amphipathic molecules, serve as indispensable tools for membrane protein solubility and stability, a prerequisite for downstream characterizations. However, membrane proteins in a conventional detergent tend to aggregate with time. To resolve an issue associated with membrane proteins stability, we developed steroidal amphiphiles with a penta-saccharide head group, designated as steroid-based penta-saccharides amphiphiles (SPSs). When these agents were evaluated for their ability to stabilize a diverse range of membrane proteins, some SPSs conferred marked stability to membrane proteins tested here compared to a conventional detergent. |
| E-mail |
ehsan.sahalwi@gmail.com |
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121st General Meeting of the KCS