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|
| Type |
Poster Presentation |
| Area |
Inorganic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
INOR.P-109 |
| Subject |
Single cell manipulation by magnetic nanoparticle cloaking |
| Authors |
Jiseong Park, Daeha Seo*
Department of Emerging Materials Science, Daegu Gyeongbuk Institute of Science & Technology, Korea
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| Abstract |
Although most of the research on cellular phenotype has focused on genetic and chemical factors, physical parameters such as diffusion dynamics, density of cells and distance between cells are non-negligible factors because of complex signaling network of cells. To manipulate physical parameters, mechanical force generator at the cellular level is needed. Magnetic nanoparticles (MNPs) can be a good tool to solve some biological questions due to their inherent magnetic property. Herein, we synthesized MNPs and conducted additional surface chemistry to ensure the dispersion stability of MNPs in aqueous phase and to prevent nonspecific binding with other biomolecules. Due to the non-interfering property of cloaking nanoparticles, it can manipulate single cells without affecting the original function of cellular components. Also, by using the functional groups obtained from surface chemistry, MNPs are conjugated with gold nanoparticles that show optical properties in visible region. We confirmed optical properties of the hybrid nanoparticle by using dark-field scattering microscopy. The hybrid structure will be advantageous for studying the mechanisms of various phenomena at the single molecular level as well as at the single cellular level. |
| E-mail |
pjs0924@dgist.ac.kr |
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121st General Meeting of the KCS