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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-606 |
| Subject |
Development of Quinoline Derivatives as a Tau-selective Fluorescence Imaging Probe |
| Authors |
Wonhee Jung, Nakcheol Jeong, GYO CHANG KEUM1,*
Department of Chemistry, Korea University, Korea
1Chemoinformatics Research Center, Korea Institute of Science and Technology, Korea
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| Abstract |
Alzheimer’s disease (AD) is one of the tauopathy which belongs to a class of neurodegenerative disease associated with the pathological aggregation of tau protein in the human brain. Neurofibrillary tangles (NFTs) are formed by aggregation of tau protein in insoluble form called PHF-tau (paired helical filament), which is leaded to abnormal mutation or hyper-phosphorylation of tau protein. The density and neocortical spread of NFTs correlate well with progressive neuronal degeneration and cognitive decline in AD patients, thus NFTs are the desirable biomarker for AD. So we are trying to develop a tau protein imaging probe based on the electron donor-π-acceptor architectur for early diagnosis of AD. Here we will present the fluorescent quinoline derivatives for the tau-selective imaging probe. |
| E-mail |
whas35@kist.re.kr |
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121st General Meeting of the KCS