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|
| Type |
Poster Presentation |
| Area |
Material Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
MAT.P-428 |
| Subject |
Anti-biofouling property of poly(ethylene glycol) coated nanoparticle/polyurethane film |
| Authors |
Hyoung-Jun Kim, Jae-Min OH*
Chemistry and Department of Medical Chemistry, Yonsei University, Korea
|
| Abstract |
The formation of biofilm on medical products can reduce their performance and cause secondary infection to patient. In order to enhance anti-biofouling property of medical products, we coated poly(ethylene glycol)-amine molecular weight 5,000 (PEG) on nanoparticle (NP; bentonite or TiO2) coated polyurethane (PU) film to decrease surface energy through increasing surface roughness and introducing mobility molecule on film surface. The cell viability assay of PEG coated NPs on human bronchial epithelial BEAS-2B cell culture line exhibited that the IC50 values of PEG coated bentonite and TiO2 are 97.5 μg/mL and 110.0 μg/mL, respectively. Nanoparticle (bentonite or TiO2) coated PU film (NP/PU film) was coated with 0.1 mg/mL PEG solution through dip-coating at 0.05 mm/s speed and then the coating solution was dried at 100°C for 30 min resulting in 5 μm and 6 μm thickness and 2H hardness by pencil test, respectively. In order to confirm the surface roughness of PEG coated NP/PU film, we utilized atomic force microscopy. The surface roughness of poly urethane film increased from 3.31 nm to 11.2 nm and 19.9 nm for PEG /bentonite/PU film and PEG /TiO2/PU film, respectively, suggesting that the decreased surface energy of PU film. The anti-biofouling property was evaluated by exposing the PEG coated NP/PU film and neat PU film to mucin and quantifying adhered mucin amount through Alcian blue staining assay. The anti-biofouling property was enhanced 95.8 % and 92.2% for PEG/bentonite/PU film and PEG /TiO2/PU film compared with neat PU film, respectively. |
| E-mail |
hjun.kim@yonsei.ac.kr |
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121st General Meeting of the KCS