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|
| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-432 |
| Subject |
Organocatalytic asymmetric Michael additions of ketones to α,β-unsaturated nitro compounds
|
| Authors |
jae ho shim, Deok-Chan Ha*
Department of Chemistry, Korea University, Korea
|
| Abstract |
The organic catalyst (R,R)-1,2-diphenylethylenediamine derivatives were developed as a chiral bifunctional organocatalysts and successfully applied to asymmetric Michael additions of ketone to α,β-unsaturated nitro compounds (up to 80% yield, 98% ee) under neutral condition. Systematic investigations on the catalytic mechanism revealed that the role of the thiourea moiety and the amine-moiety in catalysts might be reversed with respect to Brønsted/Lewis acidic or basic functionalities, depending on the reaction conditions. Generally, thiourea catalysts in neutral condition give high chemical yields and enantioselectivities.
|
| E-mail |
shimjh3000@korea.ac.kr |
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121st General Meeting of the KCS