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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-435 |
| Subject |
Prostate Tumor Imaging by Monoamine Oxidase Targeting Two Photon Agent |
| Authors |
Hayeon Lim, Jongseung Kim*
Department of Chemistry, Korea University, Korea
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| Abstract |
A MAO-A enzyme which mediates hypoxia through an elevation of ROS enhancing tumor growth is overexpressed in prostate cancer cells. With the aim of selective imaging of prostate cancer cells, we have designed the probe PTTP-1 which is consists of a MAO-A inhibitor as a prostate cancer-targeting moiety and a rhodamine derivative as a two-photon fluorophore having a mitochondria-targeting ability. And we have evaluated its optical properties, selectivity for prostate cancer cells, inhibition ability of MAO-A, and mitochondrial localization. PTTP-1 showed a specificity for prostate cancer cell lines (LNCaP and PC3) which overexpress the MAO-A over normal cells and an accumulation in the mitochondria which could be detected by a confocal microscopy. Also it has an ability to suppress the cancer cell growth by inhibition of MAO-A activities. From these results, we have proved that PTTP-1 has a remarkable selectivity towards prostate cancer cells. Therefore, it can be used as a selective bioimaging agent for prostate cancer cells. |
| E-mail |
afelia257@naver.com |
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121st General Meeting of the KCS