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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-610 |
| Subject |
Two-Photon Dual Color Imaging of Sodium and calcium Ion Activities |
| Authors |
Hyeok Jin Lee, Eun-young Yoon1, BONG RAE CHO2, Jung-Nyoung Heo1,*
New Drug Discovery and Development, Chungnam National University, Korea
1Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Korea
2Department of Chemistry, Daejin University, Korea
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| Abstract |
Calcium ion acts as a secondary messenger from our body to control various functions of cells. Due to the importance of calcium homeostasis in cell membrance and cytoplasm, the concentration of calcium ions is vital for a biological activity in order to maintain homeostasis. We have designed two-photon probes for Ca2+ derived from benzothiazole fluorene as a fluorophore and aminopolycarboxylic acid as a receptor for Ca2+ respectively. In addition, we have utilized benzoxazol naphthalene derivatives for Na+ as a fluorophore and 1-aza-12-crown-4 ether as a receptor for Na+. In this way, here we will describe dual color images of sodium and calcium in living cell, and the relationship between sodium and calcium through dual color images will be helpful in physiological and pathological studies.
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| E-mail |
saezo@naver.com |
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121st General Meeting of the KCS