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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-439 |
| Subject |
Development of novel fluorescent chemosensor for progesterone based on dansyl library |
| Authors |
Seong Cheol Hong, Md Mamunul Haque1, Jun-Seok Lee1,*
Chemical Biology, University of Science & Technology, Korea
1Molecular Recognition Research Center, Korea Institute of Science and Technology, Korea
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| Abstract |
Fluorescent organic dyes have been widely used for biological chemosensor. There are two types of the fluorescence agents. First, fluorophores can be applied as an imaging tag with specific ligands for endogenous biomolecules. In this case, the fluorophores play crucial roles as a signal generator to track the targets. On the other hands, the probes which changes its fluorescent intensity or color according to condition of analytes have a high potential as a biosensor. We interested in latter case of novel fluorescence chemosensors for biomolecules and studying the mode of actions. We prepared dansyl library using combinatorial chemistry. 48-membered dansyl probes were screened to various kinds of analytes. Finally, PG-1 and PG-2 were discovered for progesterone sensor. These probes were the first chemosensors for detecting a specific steroid molecule. Our results demonstrate the potential application of fluorescent organic dyes in biosensors which will be promising and useful for bio-imaging and target indicators. |
| E-mail |
hsc@kist.re.kr |
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121st General Meeting of the KCS