121st General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code MEDI.P-612
Subject Ultra-high field T2 MRI contrast agent for organ diagnosis
Authors Ah Rum Baek, Hee-Kyung Kim1, Garam Choi, BoKyung Sung, Yongmin Chang2,*
Medical & Biological Engineering, Kyungpook National University, Korea
1Institute of Biomedical Engineering Research, Kyungpook National University, Korea
2Molecular Medicine, Kyungpook National University, Korea
Abstract

We designed small molecular T2 MRI contrast agent for liver diagnosis with dysprosium. Among lanthanide metals, dysprosium has largest magnetic moment and curie relaxation effect in ultra-high magnetic field. Then, it can be used for useful T2 contrast agent replaces iron nanoparticles. The synthesized compounds were confirmed by analytical spectroscopic methods. The relaxivity was obtained with inversion recovery and multi slice multi echo sequence: 9.4 T (400 MHz, bruker, Germany). Image parameters for in vivo experiment are as follows: TR = 2500 msec; TE = 18.33msec; 35 × 35 × 30 mm FOV; 128 ×128 ×30 matrix; 1.0 mm slice thickness; RARE factor = 8; scan time = 40 sec. The relaxivities in 9.4 T are 0.31, 2.60 mM-1s-1. This field-dependence relaxivity is due to increasing of curie relaxation portion that increases over external magnetic field especially in T2 relaxation. From these relaxivity results, in vivo enhancement shows 30% negative contrast enhancement than pre images. The results show that this small complex might be useful as T2 agent in ultra-high field MRI. In addition, it is also demonstrated that is valuable to diagnose liver cancer with hepatobiliary property.

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