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Type |
Poster Presentation |
Area |
Medicinal Chemistry |
Room No. |
Event Hall |
Time |
4월 19일 (목요일) 11:00~12:30 |
Code |
MEDI.P-613 |
Subject |
Identification of a natural product as an inhibitor targeting T-cell protein tyrosine phosphatase associated with type-1 diabetes |
Authors |
Do Hee Ahn, Se Jeong Kwon1, hyo jin kang2, Sang Jeon Chung3,* Pharmacy, Sungkyunkwan University, Korea 1pharmacy, Sungkyunkwan University, Korea 2Department of Chemistry, Dongguk University, Korea 3Department of Chemistry, SungKyunKwan University, Korea |
Abstract |
T-cell protein tyrosine phosphatase (TCPTP) is a classical non-receptor type PTP encoded by the PTPN2 gene. TCPTP is ubiquitously expressed in embryonic and adult cells, and highly expressed in hematopoietic tissues. TCPTP negatively regulates numerous signaling pathways like JAK/STAT pathway and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation. Altered PTPN2 expression may contribute to T1D susceptibility.
In the present work, we have screened phytochemical library consisting of 658-purified single compounds for potent and found selective inhibitors of TCPTP. After screening assay, several hit compounds were studied in detail about Ki values and inhibition types (like allosteric binding inhibitor or slow binding inhibitor). This study will lead to new direction to treat the clinical disease, type-1 diabetes.
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E-mail |
ehgml94@naver.com |
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