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| Type |
Poster Presentation |
| Area |
Physical Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
PHYS.P-153 |
| Subject |
“Multi-State” Tug-of-War model for bidirectional cargo transport by kinesin and dynein |
| Authors |
Kyujin Shin, Yo Han Song, Youngeun Han, In-Chun Jeong1, Ji-Hyun Kim1, Jaeyoung Sung1,*, Kang Taek Lee2,*
Department of Chemistry, Gwangju Institute of Science and Technology, Korea
1Department of Chemistry, Chung-Ang University, Korea
2Division of Physical Chemistry Department of Chemi, Gwangju Institute of Science and Technology, Korea
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| Abstract |
The motor proteins kinesin and dynein are known as carrying various types of cargoes such as vesicles and organelles. However, a quantitative understanding of the cargo transport dynamics by motor proteins still remain hidden. We suggest “five-state tug-of-war” model to shed light on this dynamics. The key features of our approaches are that both anterograde and retrograde movements are decomposed into “slow” and “fast” components and the ATP hydrolysis rate is subject to Michaelis-Menten enzyme kinetics. We show many different kinds of “Multi-state tug of war” model and find a proper model that provides a quantitative explanation as MSD, non-Gaussian parameter and probability distribution of cargo displacement in microtubule direction. This research can be groundwork of mathematical modeling for better quantitative explanation of experiment results for bidirectional cargo transport. |
| E-mail |
littlearch@naver.com |
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121st General Meeting of the KCS