121st General Meeting of the KCS

Type Poster Presentation
Area Electrochemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code ELEC.P-596
Subject Electrochemically selective modification of diazonium on a gold electrode for highly sensitive impedimetric DNA sensor
Authors Sujin Kang, Yang-Rae Kim*
Department of Chemistry, Kwangwoon University, Korea
Abstract Recently, various functionalized molecules are immobilized on a gold electrode surface for ultrasensitive DNA sensor. Thiol-based self-assembled monolayers have been often used on a gold electrode. However, when using this method, thiol groups can adhere to other parts. In addition, gold-thiol bonding is not stable so the thiol groups can be easily detached. Electrochemical reduction of diazonium is a more desirable strategy in a view of resistance to electrochemical perturbation and long-term stability. In this study, 4-nitrobenzenediazonium was chosen as a diazonium compound and electrochemically modified on a gold electrode. Then, nitro group was converted into amino group through electrochemical reduction processes. After glutaraldehyde treatment, probe DNA sequence for Dengue virus was finally modified for detection of target DNA. All processes were electrochemically monitored using cyclic voltammetry and electrochemical impedance spectroscopy of ferri/ferrocyanide.
E-mail rkdtnwls34@naver.com