|
Type |
Poster Presentation |
Area |
Medicinal Chemistry |
Room No. |
Event Hall |
Time |
4월 19일 (목요일) 11:00~12:30 |
Code |
MEDI.P-617 |
Subject |
Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist |
Authors |
Su-Jeong Lee, Sung Jin Cho*, Jungwook Chin*, Jina Kim New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation, Korea |
Abstract |
The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of L-threonine. |
E-mail |
su-jeong@dgmif.re.kr |
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