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| Type |
Poster Presentation |
| Area |
Material Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
MAT.P-443 |
| Subject |
Bone imaging Carbon dots using Bisphosphonate Derivatives as Biomaterial
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| Authors |
KyungKwan Lee, Chul Soon Park1, Chang-Soo Lee2,*
Hazards Monitoring Bionano Research Center, Korea Research Institute of Bioscience & Biotechno, Korea
1Polymer Engineering, Chonnam National University, Korea
2Center for Bio Nano Research, Korea Research Institute of Bioscience & Biotechno, Korea
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| Abstract |
Bone related diseases are one of the major symptom of an aging our society.
The most important thing in bone related disease are early diagnosis and early treatment. Alendronate is widely used in the treatment of bone disorders, which bears bisphosphonate group with a high affinity to Ca2+ ions related to bone mineral. In this study, we synthesized Alendronate based carbon dot (Alen-CD) using alendronate, as a carbon source, without use of any surface passivating ligands and doped atom for bone imaging. Alen-CD exhibited a high binding activity for Ca2+ ions such as hydroxyapatite (HA, the mineral component of bone), rat tiviae and zebrafish vertebrae due to the presence of bis-phosphonate group on the surface. As Alen-CDs show remarkable specificity for HA over other calcium salts, the strong affinity for zebrafish vertebrae was also observed in vivo imaging. Therefore, these superior properties of Alen-CD have potential for targeted delivery to damaged bone tissue in vitro and provide motivation for in vivo investigation
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| E-mail |
leepk812@naver.com |
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121st General Meeting of the KCS