121st General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code MEDI.P-618
Subject Nitric oxide releasing core-shell nanofibers to control NO’s release properties
Authors Yeong Rim Kim, Kihak Gwon, Min Heo, Jae Ho Shin*
Department of Chemistry, Kwangwoon University, Korea
Abstract Nitric oxide (NO), a diatomic free radical is well known as a biological messenger in several physiological roles including angiogenesis and vasodilation in human body. Recently, studies on the regenerative capacity of NO have been reported to replace costly cell therapy agents in regenerative medicine. However, previously reported studies had a significant disadvantage that is trouble in controlling the release properties of NO. Herein we fabricate core-shell nanofibers by electrospinning: N-diazeniumdiolate-based NO releasing core nanofibers modified with hydrophobic silicone/polyurethane co-polymer as a shell structure. Such core-shell nanofibers are able to control NO release kinetics by tuning the hydrophobicity and thickness of the shell. N-Diazeniumdiolate as a NO donor moiety is decomposed by hydrogen ions and releases NO. When the hydrophobic polymer applied to the surface of the core nanofiber as a shell part, it took time for the hydrogen ions to reach to the N-diazeniumdiolated core, eventually resulting in retardation of NO release. The structure of nanofibers will be characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), and contact angle measurement. Nitric oxide release properties will be monitored using a chemiluminescence nitric oxide analyzer.
E-mail ylkim@kw.ac.kr