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| Type |
Poster Presentation |
| Area |
Physical Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
PHYS.P-177 |
| Subject |
A flexibility gradient on long DNA molecules acting as a Brownian ratchet |
| Authors |
Suehyun Park, Jun Soo Kim1,*
Chemistry and Nanoscience, Ewha Womans University, Korea
1Department of Chemistry and Nanoscience, Ewha Womans University, Korea
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| Abstract |
It has been widely investigated to direct the motion of molecules and colloids in many applications in chemical, mechanical and biological sciences. Applying on and off an asymmetric potential on a positively charged nanoparticle, we observed a macroscopic rolling of a nanoparticle bound to and wrapped by double-stranded DNA molecule. The flexibility gradient on DNA molecules imitating a sequence dependent change in flexibility creates an asymmetric potential on a nanoparticle wrapped by the DNA molecule, where the flexibility gradient is constructed by decreasing the local persistence length from 50 nm to 40 nm. The number of DNA monomers wrapping a nanoparticle increases when salt concentration is low, allowing the asymmetric potential to affect a nanoparticle, and decreases when salt concentration is high, allowing the potential to barely affect. When the asymmetric potential is on, the nanoparticle rolls over a DNA molecule from less flexible regions towards more flexible regions. On the other hand, the nanoparticle freely diffuses along a DNA molecule starting from the minimum of the asymmetric potential when the asymmetric potential is off. In this study, we present a novel type of Brownian ratchet using biomolecules and a strategy that can be employed in structural DNA nanotechnology. |
| E-mail |
eigrisi@hanmail.net |
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121st General Meeting of the KCS