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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-468 |
| Subject |
Synthesis of Ascorbic acid and Dehydroascorbic acid derivatives with Amine-based functional groups |
| Authors |
Seongjoo Park, do hun Lee, Dai Il Jung*, JUNGTAI HAHN1
Department of Chemistry, Dong-A University, Korea
1Department of Beauty Care, U1 University, Korea
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| Abstract |
Ascorbic acid is a naturally occurring organic compound with antioxidant properties. Because it is derived form glucose, many animals are able to produce it, but humans require it as part of their nutrition. Intravenous high-dose ascorbate is being used as a chemotherapeutic and biological response modifying agent. It should be obtained by food sources and transmitted to the brain from the bloodstream. However, ascorbic acid can not cross the blood brain barrier (BBB). Dehydroascorbic acid is an oxidized form of ascorbic acid and is actively transported through the blood brain barrier by the glucose transporter and then converted back to ascorbic acid for brain retention. It is also known to protect nerve damage after ischemic stroke.
In this study, amine groups were introduced to dehydroascorbic acid to mimic or interfere with the action of natural amine neurotransmitters in order to find application such as antidepressants or analgesics. Moreover, esterification of ascorbic acid was done in order to aid in the brain delivery. Fast delivery is expected to exhibit quicker effects and fewer side effects. We tried synthesis of dehydroascorbic acid derivatives with amine-based functional groups.
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| E-mail |
sungjoo555@naver.com |
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121st General Meeting of the KCS