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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-621 |
| Subject |
Synthesis of biodegradable nanofibers as a nitric oxide (NO) storage and delivery scaffold |
| Authors |
Kihak Gwon, Jae Ho Shin*, Yeong Rim Kim
Department of Chemistry, Kwangwoon University, Korea
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| Abstract |
Nitric oxide (NO) is one of the smallest gaseous mediators and has been involved in a variety of physiological processes such as angiogenesis, apoptosis, immune response, vasodilation, and wound healing. These versatile functions have motivated researchers to develop diverse NO storage and release system for numerous biomedical applications. Several synthetic NO releasing materials have been extensively explored to store and deliver NO safely and effectively. Especially, electrospun nanofibers as NO carriers have been received a great interest due to their simple fabrication, high surface area, facile functionalization, and tunable mechanical properties. Recently, our laboratory has developed a series of NO-releasing nanofibers via sol-gel chemistry for covalent bonding between N-diazeniumdiolate-modified aminoalkoxysilane and silyl-modified polymethylmethacrylate (PMMA), exhibiting tunable NO storage amount and release kinetics. However, PMMA-based nanofibers are difficult to be degraded in physiological conditions, eventually restricting its biomedical applications. Herein, we demonstrate the synthesis of NO-releasing, biodegradable nanofibers using a natural polymer, hyaluronic acid as a backbone polymer. NO donor N-diazeniumdiolates are covalently bound to hyaluronic acid via use of appropriate conjugation chemistry. Various synthetic parameters are tuned to control fiber diameter, degradability, and NO release properties (e.g., total NO release amount, half-life time, and maximum flux). |
| E-mail |
khgwon@kw.ac.kr |
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121st General Meeting of the KCS