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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-622 |
| Subject |
Design, Synthesis and Biological evaluation of Non-Steroidal Scaffold Derivatives as TGR5 Agonist |
| Authors |
Chang Yong Lee, SeHee Jang1, Hun Yeong Koh*
Department of Chemistry, Inha University, Korea
1Inha University, Korea
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| Abstract |
Type 2 diabetes is a disease that causes the higher blood glucose level when there is the reduced insulin sensitivity or a problem with insulin secretion. Therefore, the aim of diabetes treatment is to lower blood glucose levels by promoting glucagon-like peptide-1(GLP-1) secretion1. GLP-1 is regulated by the Takeda G-protein coupled receptor5 (TGR5) which is one of the G- protein-coupled receptors(GPCR) for bile acid. In this study, new 7-(pyridine-4-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine derivatives were synthesized by Suzuki-Miyaura coupling reaction using microwave reactor2 and evaluated their biological activities in vitro |
| E-mail |
lcyong4202@gmail.com |
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121st General Meeting of the KCS