Mesoporous hydroxyapatite nanoparticles are promising materials for application of artificial bone and have been widely investigated for control drug release purpose. But due to the nature of fast mineralization, it is hard to control their crystalline structure and modify surface properties in order to load bioactive molecules. Nonetheless, we synthesized mesostructure hydroxyapatite by controlling the concentration of the surfactant (Cetyl TrimethylAmmonium Bromide(CTAB)) and the reaction temperature. Through the above control, it was possible to make a mesostructure composed only of hydroxyapatite without template like silica compound. The structural integrity was characterized by IR spectroscopy, powder X-ray diffraction, scanning electrons microscopy, transmission electron microscopy and BET gas adsorption. Furthermore a large surface area of hydroxyapatite can be used to load the drug, and a functional group capable of tracking the lesion on the surface can be attached to control the drug to be administered to the affected area.