121st General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code ORGN.P-472
Subject Reactions of 1,3,5-Triazacyclohexanes and acid-degradable cationic polyacrylates as siRNA delivery vehicles
Authors Seongjoo Park, Soo Kyung Cho, Dai Il Jung*, JUNGTAI HAHN1
Department of Chemistry, Dong-A University, Korea
1Department of Beauty Care, U1 University, Korea
Abstract The development of safe and efficient delivery vehicle is still the core of gene therapy technology after decades of vigorous research. Dendrimers have long been studied as nucleic acid therapeutics carriers owing to many advantages such as monodispersity, multivalency and large surface area. However, their rigidity and possible cytotoxicity stemming from the large surface have prevented them from being a successful siRNA delivery vehicle. Our group is interested in developing star polymers with a degradable dendrimer-like core for enhanced flexibility and reduced toxicity. In this study, a degradable 1,3,5-triazacyclohexane core synthesized from an amino acid reacted with degradable polyacrylates to form a fully degradable star polymers. High flexibility is expected from flexible core and star-shaped branches. Moreover, degradable core synthesized from amino acid and degradable ketal branches are expected to reduce the cytotoxicity as well. Spectroscopic characterization, polyplex morphology characterization as well as in vitro cytotoxicity and gene silencing efficiency will be discussed.
E-mail sungjoo555@naver.com