We developed multicomponent reactions of carbon-carbons multiple bonds for the synthesis of trifluoromehtyl incorporated molecules. It is difficult to synthesize to make such compounds with conventional methods. Mild reaction conditions utilizing photoredox catalysis enable to generate the CF3 containing complex molecules. The CF3 incorporated radical intermediates can be used for further coupling with other nucleophiles. With this platform in hands, various type of reactions are developed. In addition, biologically active compounds were applied under the condition to obtain desired products, suggesting that the method could be feasible for late-stage modification in drug discovery.
References
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