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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-474 |
| Subject |
Synthesis and photophysical characterization of the fluorene-linked 2’-deoxyuridine |
| Authors |
So Young Lee, Gil Tae Hwang*
Department of Chemistry, Kyungpook National University, Korea
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| Abstract |
Fluorescent nucleoside analogs that are sensitive to their local environment, demonstrating changes in the fluorescent properties when induced by changes in polarity, pH, or even structure, have become powerful tools for the investigation of nucleic acid structure, dynamics, and recognition.
In this study, we synthesized the fluorene-linked 2’-deoxyuridine through the Suzuki coupling of 5-iodo-2’-deoxyuridine with fluorene-2-boronic acid pinacol ester and investigated its solvent-dependent photophysical properties.
In addition, we incorporated it into the central position of oligodeoxynucleotide to investigate the potential as a SNP probe upon the duplex formation with fully matched and single-base mismatched targets. Detailed research results including these will be presented. |
| E-mail |
som0544@naver.com |
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121st General Meeting of the KCS