121st General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code ORGN.P-476
Subject Enantioselective Liquid–Liquid Extraction of Amino Acids by Naphthol Derivatives Contaning Asymmetric Carbon
Authors YINGJI JIN, kwan mook kim1,*
Nano chemistry, Ewha Womans University, Korea
1Department of Chemistry, Ewha Womans University, Korea
Abstract Novel chiral extractants 2 and 3 were synthesized from 3-hydroxy-2-naphthoic acid and applied in the enantioselective liquid–liquid extraction (ELLE) of Amino Acids. 2 and 3 were firstly synthesized in racemic form and then obtained their optically pure form by normal silica column chromatography seperation from the imine diastreomers which was obtained by the reaction of racemic mixture of 2 and 3 with optically pure 2-Amino-2-Phenylethanol and phenylalanine respectively. Different with the developed axially chiral Binol-based chiral extractants, 2 and 3 used asymmetric carbon to control the stereoselectivity. The efficiency and activity of 2 and 3 in ELLE for amino acids was determined by 1H NMR analysis. The results showed that chiral receptors with asymmetric carbon can also gave good selectivity to amino acids in ELLE process. Moreover, tert-butyl ketone-based 3 exhibited much higher selectivity than extractant 2 containing aldehyde group.
E-mail jinyingji1121@live.cn