|
Type |
Poster Presentation |
Area |
Organic Chemistry |
Room No. |
Event Hall |
Time |
4월 19일 (목요일) 11:00~12:30 |
Code |
ORGN.P-476 |
Subject |
Enantioselective Liquid–Liquid Extraction of Amino Acids by Naphthol Derivatives Contaning Asymmetric Carbon |
Authors |
YINGJI JIN, kwan mook kim1,* Nano chemistry, Ewha Womans University, Korea 1Department of Chemistry, Ewha Womans University, Korea |
Abstract |
Novel chiral extractants 2 and 3 were synthesized from 3-hydroxy-2-naphthoic acid and applied in the enantioselective liquid–liquid extraction (ELLE) of Amino Acids. 2 and 3 were firstly synthesized in racemic form and then obtained their optically pure form by normal silica column chromatography seperation from the imine diastreomers which was obtained by the reaction of racemic mixture of 2 and 3 with optically pure 2-Amino-2-Phenylethanol and phenylalanine respectively. Different with the developed axially chiral Binol-based chiral extractants, 2 and 3 used asymmetric carbon to control the stereoselectivity. The efficiency and activity of 2 and 3 in ELLE for amino acids was determined by 1H NMR analysis. The results showed that chiral receptors with asymmetric carbon can also gave good selectivity to amino acids in ELLE process. Moreover, tert-butyl ketone-based 3 exhibited much higher selectivity than extractant 2 containing aldehyde group. |
E-mail |
jinyingji1121@live.cn |
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