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|
| Type |
Poster Presentation |
| Area |
Physical Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
PHYS.P-184 |
| Subject |
Targeting the cell organelle and the effect of cell division using Upconversion nanoparticles (UCNPs) |
| Authors |
Yeongchang Goh, Yo Han Song, Kang Taek Lee1,*
Department of Chemistry, Gwangju Institute of Science and Technology, Korea
1Division of Physical Chemistry Department of Chemi, Gwangju Institute of Science and Technology, Korea
|
| Abstract |
Lanthanide-doped upconversion nanoparticles (UCNPs) are useful probes in living cells because of a number of advantages such as photostability (no photoblinking and no photobleaching), minimized cellular autofluorescence and low level of photodamage to cells by the near infrared excitation. Recently, we took the advantages of UCNPs for 3D real-time imaging. The cellular uptake of nanoparticles is a dynamic process where the nanoparticles are internalized by mechanisms such as ATP hydrolysis-driven endocytosis and delivered to the cytoplasm, organelles, and nucleus. The number of internalized nanoparticles is important factor for the efficiency of drug or gene delivery system. However, the internalized nanoparticles can be diluted by cellular process such as cell division. To evaluate the number of internalized nanoparticles after cell division, UCNPs are targeted to cell organelles such as nucleus, mitochondria, etc. |
| E-mail |
kyc940409@gist.ac.kr |
|
121st General Meeting of the KCS