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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-479 |
| Subject |
Highly Enantioselective and Practical Resolution of Underivatized Amino Acids by Liquid-Liquid Extraction Using a tert-Butyl Ketone-based Binol |
| Authors |
HAOFEI HUANG, kwan mook kim1,*
Nano chemistry, Ewha Womans University, China
1Department of Chemistry, Ewha Womans University, Korea
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| Abstract |
Using a novel synthesized t-butyl ketone (s)-3 in the enantioselective liquid-liquid extraction process allowed the seperation of D-amino acids from enantiomers in enantiomeric excess of 99% and 90%~98% yields. Compared with other ketone-derivatives, such as mehtyl, ethyl and iso-propyl ketones, (s)-3 showed much higher reaction speed, yield and enantioselectivity in the imine formation with amino acids. Calculations for the energy-minimized structures and NMR analysis indicated that the tert-butyl moiety played an outstanding role in the stability of imine and the resolution. Moreover, facilitated by the fast and easy hydrolysis of imine, (s)-3 could be very suitable in continuous extraction procedure. |
| E-mail |
1982hhf@163.com |
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121st General Meeting of the KCS