|
|
| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-627 |
| Subject |
Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid-Phase Synthetic Approaches |
| Authors |
GeunHyung Jo, YunJi Jin, Taeho Lee1,*
Kyungpook National University, Korea
1Department of Pharmacy, Kyungpook National University, Korea
|
| Abstract |
Efficient synthesis method for the preparation of secondary 1,2,3-triazoloamide derivatives were developed. A secondary α-1,2,3-triazoloamide library was constructed and expanded by a previously developed solid-phase synthetic route. The synthetic routes rely on amide formation with secondary amines and chloro-acid chlorides; SN2 reaction with sodium azide; and the selective [3 + 2] Hüisgen cycloaddition with appropriate terminal alkynes. The target secondary 1,2,3-triazoloamide derivatives were obtained with three-diversity points in excellent overall yields and purities using the reported solid-phase synthetic routes, respectively |
| E-mail |
cgh0605@naver.com |
|
121st General Meeting of the KCS