|
Type |
Poster Presentation |
Area |
Physical Chemistry |
Room No. |
Event Hall |
Time |
4월 20일 (금요일) 11:00~12:30 |
Code |
PHYS.P-195 |
Subject |
Nanoparticle positioning on the patterned DNA with varying sequence-dependent flexibility |
Authors |
Jeongeun Song, Suehyun Park, Jun Soo Kim* Department of Chemistry and Nanoscience, Ewha Womans University, Korea |
Abstract |
DNA molecules have been actively researched in various areas such as genetics and nanotechnology because of its high utilization. In this work, we present a computational study on controlling DNA conformations by binding with positively charged nanoparticles, using Brownian dynamics simulations. Especially, we construct various patterned sequences of DNA molecule on which local flexibility varies with the sequence and investigate the binding of nanoparticles on the patterned DNA that depend on local flexibilities. The difference between flexible and stiff regions in a DNA chain results in nanoparticle positioning on specific regions in DNA. In intermediate concentration of nanoparticles, DNA and nanoparticles were observed to bind at the flexible sites of the DNA molecule. Whereas at high concentration of nanoparticles, aggregation of the nanoparticles bound to DNA occurs. |
E-mail |
ageun1213@gmail.com |
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