121st General Meeting of the KCS

Type Poster Presentation
Area Physical Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code PHYS.P-195
Subject Nanoparticle positioning on the patterned DNA with varying sequence-dependent flexibility
Authors Jeongeun Song, Suehyun Park, Jun Soo Kim*
Department of Chemistry and Nanoscience, Ewha Womans University, Korea
Abstract DNA molecules have been actively researched in various areas such as genetics and nanotechnology because of its high utilization. In this work, we present a computational study on controlling DNA conformations by binding with positively charged nanoparticles, using Brownian dynamics simulations. Especially, we construct various patterned sequences of DNA molecule on which local flexibility varies with the sequence and investigate the binding of nanoparticles on the patterned DNA that depend on local flexibilities. The difference between flexible and stiff regions in a DNA chain results in nanoparticle positioning on specific regions in DNA. In intermediate concentration of nanoparticles, DNA and nanoparticles were observed to bind at the flexible sites of the DNA molecule. Whereas at high concentration of nanoparticles, aggregation of the nanoparticles bound to DNA occurs.
E-mail ageun1213@gmail.com