121st General Meeting of the KCS

Type Poster Presentation
Area Material Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code MAT.P-475
Subject Gadolinium-complex incorporated layered double hydroxide with homogeneous size through reverse micelle method
Authors Sang-Yong Jung, Hyoung-Mi Kim, Tae-Hyun Kim, Jae-Min OH*
Chemistry and Department of Medical Chemistry, Yonsei University, Korea
Abstract Layered double hydroxide (LDH), which is also known as anionic clay, is one of the emerging nanomaterials in drug delivery application. We have synthesized gadolinium (Gd) complex incorporated LDH for potential application in magnetic resonance imaging contrasting agent considering long-term circulation and bypassing macrophages, the size of Gd-LDH was homogeneously controlled by reverse-micelle method. First, we tried well-known dodecyl-sulfate based micelle in octane and butanol solvent. We could obtain LDH phase, however, the surfactant dodecyl sulfate was incorporated instead of Gd-complex, Thus, we changed surfactant to cationic one, cetyltrimethylammonium bromide (CTAB), typically, CTAB and cyclohexane solution was prepared. First, we obtained LDH through reverse micelle method without Gd-complex with two different composition utilizing Mg2+ and Al3+ for MgAl-LDH-RM and Mg2+ and Ga3+ for MgGa-LDH-RM, respectively. The X-ray diffraction (XRD) patterns, prepared LDHs shows typical 2-dimensional layered structure like hydrotalcite (JCPDS No. 14-0191) having 0.33nm of interlayer space which is not enough space for surfactant CTAB. Then we synthesized Gd-complex incorporated LDHs through same reverse micelle method following previous experimental procedure with diethylenetriaminepentaacetic acid Gadolinium (III) solution and was named MgAl-Gd-LDH-RM and MgGa-Gd-LDH-RM, respectively. From XRD patterns and Fourier-transform infrared spectra, we confirmed that prepared Gd-complexes were successfully incorporated with LDHs through reverse micelle method utilizing CTAB. We also investigated the Hounsfield unit (HU) and T1 relaxivity of prepared samples with microCT and magnetic resonance imaging instrument, respectively.
E-mail syjung05@naver.com