Synthesis of polycyclic compound has been a major challenge in modern synthetic organic chemistry due to the large appearance of biologically active natural products possessing polycyclic rings. Triynes can be converted into polycyclic compounds with the help of the transition metal catalysts like palladium, rhodium, nickel, and cobalt. Continuing our interest in palladium catalyzed polycyclization, we revisited [2+2+2] triyne cyclization to synthesize the Alcyopterosin natural products. We will report the synthesis of Alcyopterosin Natural product focus on chiral type.