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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-486 |
| Subject |
A Two-photon NIR Probe for Spatiotemporal Tumor Therapy |
| Authors |
Hae-Jo Kim*, HyunSeok Seo
Department of Chemistry, Hankuk University of Foreign Studies, Korea
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| Abstract |
Background: Development of a method to control the function of compounds in a spatiotemporal manner is indispensable in the field of biological chemistry and drug delivery. Ultraviolet (UV) irradiation-induced bond cleavage reaction or conformational change of backbone has been applied in order to control function. However, due to its low short wavelength, UV light exhibits limited penetration depth in biological tissues and can possibly cause tissue damage, which hampers the application of UV light for the treatment of internal tumors.1,2
Near-infrared (NIR) two-photon photolysis can overcome these problems because NIR causes minimal tissue damaging compared with UV. Over the past few decades, NIR light-triggered photodynamic therapy (PDT) has emerged as an alternative treatment approach to chemotherapy and radiotherapy to treat cancer in the clinic.3,4
Materials and Method: Chemical probe was prepared according to the standard method in the lab and all reagents purchased from the chemical suppliers.
Conclusion: We design a NIR two photon-induced drug delivery system for tumors. For targeting tumor, a glucose unit is introduced as a biomarker and a two-photon active nitrobenzyl ether moiety is linked to a drug moiety. This probe is expected to exhibit an effective spatiotemporal tumor therapy in a mouse model of cancer.
References
1 S. Akira , O. Akira, Tetrahedron Lett., 2010, 51, 2868.
2 M. XingGuo, Biomat., 2015, 48, 84.
3 R. Weissleder, Nat Biotechnol., 2001,19, 316.
4 T. W. Hambley , Cancer Res., 2009, 69, 1259.
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| E-mail |
makt91@nate.com |
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121st General Meeting of the KCS