Diels-Alder reaction of 2-pyrone can be exceptionally powerful for the synthesis of structurally complex natural products, constructing multiple carbon-carbon bonds in a single operation1. As a part of our ongoing study exploring the utility of 3,5-dibromo-2-pyrone in target-oriented synthesis2, we have further envisioned that the aforementioned synthetic strategy could be also effective for clivonine. Our efforts toward this natural product will be presented.