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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-631 |
| Subject |
Synthesis and evaluation of novel multi-chelator tether for mAb radiolabeling |
| Authors |
Heejung Kim*, Hyeonsu Na1, ILJUNG LEE*, Eunbi Shin, Jai Woong Seo2
Korea Institute of Radiological & Medical Science, Korea
1Department of Chemistry, Inha University, Korea
2Department of Biomedical Engineering, University of California, Davis, United States
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| Abstract |
Monoclonal antibody (mAb) can be labeled with various radiometals for imaging or targeted radionuclide-therapy applications. Although several numbers of amine or cysteine on mAb can be conjugated with NCS-, NHS-, or maleimide-chelator, there is a limited number of available amine or cysteine for radiolabeling. In this study, we designed multi-chelator tether having several chelators. Multi-chelator tether was synthesized via solid phase peptide synthesis (SPPS) and evaluated for its labeling efficiency with 64Cu. And also we evaluated its stability using rat and human serum in vitro. Multi-chelator tether is expected to increase the specific activity of radiolabeled mAb without depleting available amine or cysteine on the mAb. |
| E-mail |
heejung.kim@kirams.re.kr |
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121st General Meeting of the KCS