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|
| Type |
Poster Presentation |
| Area |
Polymer Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
POLY.P-43 |
| Subject |
The preparation and evaluation of glabridin nanosuspension for skin whitening |
| Authors |
Minseop So*, SeoYeong Lee1
Department of New drug development, Chungnam National University, Korea
1Korea Research Institute of Chemical Technology, Korea
|
| Abstract |
It has been reported that glabridin extracted from Glycyrrhiza glabra has an excellent effect on the anti-tyrosinase activity for inhibiting melanin synthesis.
However, glabridin or various whitening functional ingredients are hydrophobic and have low solubility in water, therefore they are difficult to be used as functional cosmetics for whitening.
In this study, a biocompatible polymer, such as lutrol F 127, was used to increase solubility of glabridin and whitening functional materials in order to remedy the disadvantage of poor solubility.
As a result, the solubility of poorly soluble glabridin was improved by using a biocompatible polymer, and it was confirmed by measuring the particle size was measured by DLS analysis which was 20-150 nm, the skin permeability of the active substance was improved and the long - term stability was excellent. In addition, as a result of measuring the inhibitory activity of tyrosinase activity of glabridin, it was confirmed that the effect of suppressing tyrosinase activity was more than 80% even though concentration of the active substance was as low as 0.001%.
in vitro whitening effect test of glabridin micelle nanoparticle material through the melanogenesis inhibition assay was confirmed to be effective from 0.005%. which indicates about 40% more inhibitory activity than the control group arbutin.
The skin permeability of solubilized glabridin in 24 hours was 8%, and permeability of solubilized glabridin was increased up to 21% when a certain amount of skin permeation enhancer was added.
In conclusion, it was confirmed that the glabridin solubilized using biocompatible polymer has a great effect on inhibition of melanin formation and is effective as a whitening functional product.
S2411108 |
| E-mail |
totor_@naver.com |
|
121st General Meeting of the KCS